Automation of immunohematology testing has developed a stronger foothold in many transfusion services as instrument capability and software resourcefulness have expanded the safety and security of testing. Automation does not necessarily meet all laboratories needs due to economic feasibility and operational volumes. However, it has been shown that full automation can minimize risks, therefore, solutions for transfusion services that do not use fully automated systems need to be designed to reduce risks. In laboratories reliant on manual methods, a semiautomated solution would address this need. Using elements of a full automation instrument imaging system and software, a new reader system, ORTHO OPTIXTM Reader (OPTIX) was developed. This study validated the performance of the reader compared to the ORTHO VISION® Analyzer (VISION) for concordance.